| William Shakespeare (1564–1616), English poet, player and playwright |
| Shalmaneser, name of three Assyrian princes |
| Shamil (1798?–1871), the leader of the tribes of the Caucasus in the war against Russia |
| Shammai (First Century B.C.–First Century A.D.), Jewish scribe |
| Charles Shannon (1863–1937), English artist |
| James Jebusa Shannon (1862–1923), Anglo-American artist |
| Mozes Ṿilhelm Shapira (c. 1830–1884), Polish vendor of spurious antiquities |
| Shāpūr, name of three Sassanian kings |
| Vishnu Sharma (Pilpay) (c. 1000 B.C.?), name given to a famous collection of Hindu stories |
| Granville Sharp (1735–1813), English philanthropist |
| James Sharp (1613–1679), Scottish divine |
| John Sharp (1645–1714), English divine, Archbishop of York |
| Richard Sharp (1759–1835), known as “Conversation Sharp,” |
| William Sharp (1749–1824), English line-engraver |
| Daniel Sharpe (1806–1856), English geologist |
| Anna Howard Shaw (1847–1919), American reformer |
| Byam Shaw (1872–1919), English painter |
| George Bernard Shaw (1856–1950), British dramatist |
| Lemuel Shaw (1781–1861), American jurist |
| Richard Norman Shaw (1831–1912), English architect |
| Daniel Shays (1747–1825), American soldier |
| John Gilmary Shea (1824–1892), American historian |
| Thomas Shearer (fl. 1788), English furniture designer and cabinet-maker |
| Thomas Gaskell Shearman (1834–1900), American lawyer and publicist |
| William Greenough Thayer Shedd (1820–1894), American Presbyterian |
| Sir Martin Archer Shee (1769–1850), English portrait-painter and President of the Royal Academy |
| John Sheepshanks (1787–1863), British manufacturer and art collector |
| John Holroyd, Earl of Sheffield (1735–1821), English politician |
| Richard Lalor Sheil (1791–1851), Irish politician and writer |
| Isaac Shelby (1750–1826), American soldier and pioneer |
| Charles Monroe Sheldon (1857–1946), American Congregational clergyman |
| Gilbert Sheldon (1598–1677), Archbishop of Canterbury |
| Mary Wollstonecraft Shelley (1797–1851), English writer |
| Percy Bysshe Shelley (1792–1822), English poet |
| Frederick William Shelton (1814–1881), American clergyman and author |
| Thomas Shelton (fl. 1612–1620), English translator of Don Quixote |
| Shem, in the Bible, the eldest of the three sons of Noah |
| William Shenstone (1714–1763), English poet |
| Jack Sheppard (1702–1724), English criminal |
| Theophilus Shepstone (1817–1893), British South African statesman |
| Thomas Sheraton (1751–1806), Next to Chippendale the most famous English furniture-designer and cabinet-maker |
| Robert Lowe, Viscount Sherbrooke (1811–1892), British statesman |
| Shere Ali Khan (1825–1879), Amir of Afghanistan |
| Sheridan, name of an Anglo-Irish family |
| Philip Henry Sheridan (1831–1888), American general |
| Richard Brinsley Sheridan (1751–1816), eminent British dramatist and parliamentary orator |
| Sherif Pasha (1826–1887), Egyptian statesman |
| Thomas Sherlock (1678–1761), English divine |
| William Sherlock (1641?–1707), English divine |
| James Schoolcraft Sherman (1855–1912), American politician |
| Frank Dempster Sherman (1860–1916), American poet |
| John Sherman (1823–1900), American financier and statesman |
| Roger Sherman (1721–1793), American political leader |
| William Tecumseh Sherman (1820–1891), American general |
| John Keyse Sherwin (1751–1790), English engraver and history-painter |
| Mary Martha Sherwood (1775–1851), English author |
| William Shield (1748–1829), English musical composer |
| James Shields (1806/10–1879), American soldier |
| Benjamin Penhallow Shillaber (1814–1890), American humorist |
| Richard Shilleto (1809–1876), English classical scholar |
| Jonathan Shipley (1714–1788), Bishop of St. Asaph |
| Sir Sidney Shippard (1838–1902), British colonial administrator |
| Edward Shippen (1729–1806), American jurist |
| Sir Anthony Shirley (1565–c. 1635), English traveller |
| James Shirley (1596–1666), English dramatist |
| William Shirley (1694–1771), colonial Governor of Massachusetts |
| Emily Anne Eliza Shirreff (1814–1897), English pioneer in the higher education for women |
| Shivaji (1627–1680), founder of the Mahratta power in India |
| Jane Shore (d. 1527), mistress of the English King Edward IV. |
| Sir Francis Job Short (1857–1945), English engraver |
| Dora Sigerson Shorter (1866–1918), Irish poet |
| John Henry Shorthouse (1834–1903), English novelist |
| Sir Clowdisley Shovell (1650–1707), English admiral |
| Earls of Shrewsbury |
| Charles Talbot, Duke of Shrewsbury (1660–1718), English noble |
| Elizabeth Hardwick Talbot, Countess of Shrewsbury (1527?–1608), “Bess of Hardwick,” English noble |
| Edward Shuter (c. 1728–1776), English actor |
| Peter Andreivich Shuvalov (1827–1889), Russian diplomatist |
| Sībawaihi (c. 753–793), Arabian grammarian |
| Sir Robert Sibbald (1641–1722), Scottish physician and antiquary |
| Hiram Sibley (1807–1888), American financier |
| John Sibthorp (1758–1796), English botanist |
| Roch-Ambroise Cucurron Sicard (1742–1822), French abbé and instructor of deaf-mutes |
| Franz von Sickingen (1481–1523), German knight, one of the most notable figures of the first period of the Reformation |
| Daniel Edgar Sickles (1819–1914), American soldier and diplomatist |
| Sarah Siddons (1755–1831), English actress |
| Eleanor Mildred Sidgwick (1845–1936), British educationalist |
| Henry Sidgwick (1838–1900), English philosopher |
| Henry Addington, Viscount Sidmouth (1757–1844), English statesman |
| Algernon Sidney (1623–1683), English politician |
| Sir Henry Sidney (1529–1586), Lord Deputy of Ireland |
| Sir Philip Sidney (1554–1586), English poet, statesman and soldier |
| Robert Sidney (1563–1626), Earl of Leicester, English statesman |
| Saint Sidonius Apollinaris (431/2–c. 487), Christian writer and Bishop |
| Carl Theodor Ernst von Siebold (1804–1885), German physiologist and zoologist |
| Philipp Franz von Siebold (1796–1866), scientific explorer of Japan |
| Werner von Siemens (1816–1892), German electrician |
| Sir William Siemens (1823–1883), British inventor, engineer and natural philosopher |
| Henryk Sienkiewicz (1846–1916), Polish novelist |
| Emmanuel Joseph Sieyès (1748–1836), French abbé and statesman |
| Xavier Sigalon (1787–1837), French painter |
| Sigebert (d. 575), King of the Franks |
| Sigebert of Gembloux (c. 1030–1112), medieval chronicler |
| Franz Sigel (1824–1902), German and American soldier |
| Siger de Brabant (Thirteenth Century), French philosopher |
| Sigismund (1368–1437), Roman Emperor and King of Hungary and Bohemia |
| Sigismund I. (1467–1548), King of Poland |
| Sigismund II. (1520–1572), King of Poland |
| Sigismund III. (1566–1632), King of Poland and Sweden |
| Luca Signorelli (1441?–1523), Italian painter |
| Carlo Sigonio (c. 1524–1584), Italian humanist |
| Lydia Huntley Sigourney (1791–1865), American author |
| Jón Sigurðsson (1811–1879), Icelandic statesman and man of letters |
| Christoph Wilhelm von Sigwart (1789–1844), German philosopher |
| Silanion (Fourth Century B.C.), Greek sculptor |
| Silas (fl. 50 A.D.), early Christian prophet and missionary |
| Étienne de Silhouette (1709–1767), Controller-general of France |
| Silius Italicus (25/6–101 A.D.), Latin epic poet |
| Edward Rowland Sill (1841–1887), American poet and educationist |
| Benjamin Silliman (1779–1864), American chemist and geologist |
| António Dinis da Cruz e Silva (1731–1799), Portuguese heroic-comic poet |
| António José da Silva (1705–1739), Portuguese dramatist |
| João Manuel Pereira da Silva (1817–1898), Brazilian historian |
| Silverius (d. 538?), Pope |
| Silvester, name of three popes |
| Armand Silvestre (1837–1901), French poet and conteur |
| Antoine Isaac Silvestre de Sacy (1758–1838), French orientalist |
| John Graves Simcoe (1752–1806), British soldier and first lieutenant-governor of Upper Canada |
| Simeon, in the Old Testament, the name of a tribe of Israel |
| Simeon of Durham (d. c. 1130), English chronicler |
| Charles Simeon (1759–1836), English evangelical divine |
| Joseph-Jérôme, Comte Siméon (1749–1842), French jurist and politician |
| Saint Simeon Stylites (390–459), first and most famous of the Pillar-hermits |
| Josias Simler (1530–1576), author of the first book relating solely to the Alps |
| Edward Simmons (1852–1931), American artist |
| William Gilmore Simms (1806–1870), American poet, novelist and historian |
| Lambert Simnel (fl. 1477–1534), English impostor |
| Theophylact Simocatta (Seventh Century), Byzantine historian |
| Abraham Simon (1622?–1692?), English medallist and modeller |
| Sir John Simon (1816–1904), English surgeon and sanitary reformer |
| John Allsebrook, Viscount Simon (1873–1954), British politician and lawyer |
| Jules Simon (1814–1896), French statesman and philosopher |
| Richard Simon (1638–1712), French biblical critic |
| Thomas Simon (c. 1623–1665), English medallist |
| Simon bar Yoḥai (Second Century), Galilean rabbi |
| Simon de Sancto Quintino (Thirteenth Century), Dominican mission-traveller and diplomatist |
| Simon of Sudbury (d. 1381), Archbishop of Canterbury |
| Simonides of Amorgos (Seventh Century B.C.), Greek iambic poet |
| Simonides of Ceos (c. 556–468 B.C.), Greek lyric poet |
| Simon Magus (First Century), character who appears in the New Testament |
| Simplicius (d. 483), Pope |
| Simplicius (Sixth Century), Greek philosopher |
| Sir James Young Simpson (1811–1870), Scottish physician |
| Matthew Simpson (1811–1884), American Bishop of the Methodist Episcopal Church |
| Thomas Simpson (1710–1761), English mathematician |
| Karl Joseph Simrock (1802–1876), German poet and man of letters |
| George Robert Sims (1847–1922), English journalist and dramatic author |
| William Sowden Sims (1858–1936), American naval officer |
| Eduard von Simson (1810–1899), German jurist and politician |
| Robert Simson (1687–1768), Scottish mathematician |
| William Simson (1800–1847), Scottish portrait, landscape and subject painter |
| Sinan Pasha (1520–1596), Turkish soldier and statesman |
| Sinclair, name of an old Scottish family |
| Sir John Sinclair (1754–1835), Scottish writer on finance and agriculture |
| Sindhia, name of a family of rulers of the Gwalior state in India |
| Satyendra Prasanna, Baron Sinha (1864–1928), Indian statesman |
| Simeon Singer (1848–1906), Jewish preacher, lecturer and public worker |
| Sir Pratap Singh (1844–1922), Maharaja of Idar, native Indian soldier and statesman |
| Siraj ud-Daula (d. 1757), ruler of Bengal |
| Siricius (d. 399), Pope |
| Jacques Sirmond (1559–1651), French scholar and Jesuit |
| Alfred Sisley (1839–1899), French landscape painter |
| Jean Charles Léonard Simonde de Sismondi (1773–1842), celebrated Swiss historian |
| Sitting Bull (1831–1890), Chief and medicine man of the Dakota Sioux |
| Camillo Sivori (1815–1894), Italian violinist |
| Siward (d. 1055), Earl of Northumbria |
| Sixtus, name of five popes |
| Friedrich Sixt von Armin (1851–1936), German general |
| Piotr Skarga (1536–1612), Polish writer and reformer |
| Walter William Skeat (1835–1912), English author |
| Sir William Skeffington (c. 1465–1535), Lord Deputy of Ireland |
| John Skelton (1460?–1529), English poet |
| William Forbes Skene (1809–1892), Scottish historian and antiquary |
| James Skinner (1778–1841), British military adventurer in India |
| John Skinner (1721–1807), Scottish author |
| Philip Skippon (d. 1660), English soldier in the Civil Wars |
| Adam Skirving (1719–1803), Scottish song-writer |
| Mikhail Dimitriévich Skobelev (1843–1882), Russian general |
| Peder Skram (c. 1500–1581), Danish senator and naval hero |
| Jan Zygmunt Skrzynecki (1787–1860), Polish general |
| Felix Slade (1790–1868), English art collector and patron |
| John Fox Slater (1815–1884), American philanthropist |
| Samuel Slater (1768–1835), American textile manufacturer |
| Rudolf Carl von Slatin (1857–1932), Anglo-Austrian soldier and administrator in the Sudan |
| Sir William Henry Sleeman (1788–1856), Indian soldier and administrator |
| Johannes Sleidanus (1506–1556), German historian, the annalist of the Reformation |
| John Slidell (1793–1871), American political leader and diplomatist |
| Sir Hans Sloane (1660–1753), British collector and physician |
| William Milligan Sloane (1850–1928), American educator and critical author |
| Henry Warner Slocum (1826–1894), American general |
| René-Michel Slodtz (1705–1764), French sculptor |
| George Washburn Smalley (1833–1916), American journalist |
| George Smalridge (1663–1719), English Bishop |
| Christopher Smart (1722–1771), English poet |
| Sir George Thomas Smart (1776–1867), English musician |
| Henry Smart (1813–1879), English organist and musical composer |
| John Smart (1741–1811), English miniature painter |
| John Smeaton (1724–1792), English civil engineer |
| Frank Edward Smedley (1818–1864), English novelist |
| William Thomas Smedley (1858–1920), American artist |
| Smerdis (d. c. 527 B.C.), Persian King of infamous memory |
| Pierre-Jean de Smet (1801–1873), Belgian missionary |
| Bedřich Smetana (1824–1884), Bohemian composer and pianist |
| John Smibert (1688–1751), Scottish-American artist |
| Samuel Smiles (1812–1904), British author |
| James David Smillie (1833–1909), American artist |
| Robert Smillie (1857–1940), British labour politician |
| Robert Smirke (1752–1845), English painter |
| Adam Smith (1723–1790), English economist |
| Albert Smith (1816–1860), English author and public entertainer |
| Alexander Smith (1830–1867), Scottish poet |
| Alfred Emanuel Smith (1873–1944), American politician |
| Andrew Jackson Smith (1815–1897), American soldier |
| Buckingham Smith (1810–1871), American antiquarian and historian |
| Charles Emory Smith (1842–1908), American journalist and political leader |
| Charles Ferguson Smith (1807–1862), American soldier |
| Charlotte Smith (1749–1806), English novelist and poet |
| Colvin Smith (1795–1875), Scottish portrait-painter |
| Edmund Kirby Smith (1824–1893), Confederate general in the American Civil War |
| Eli Smith (1801–1857), American missionary |
| Erminnie Adele Smith (1836–1886), American scientist |
| Francis Hopkinson Smith (1838–1915), American author, artist and engineer |
| George Smith (1789–1846), British publisher |
| George Smith (1831–1895), English philanthropist |
| George Smith (1840–1876), English Assyriologist |
| Sir George Adam Smith (1856–1942), Scottish divine |
| George Barnett Smith (1841–1909), English author and reviewer |
| Gerrit Smith (1797–1874), American reformer and philanthropist |
| Goldwin Smith (1823–1910), British historian and publicist |
| Henry Boynton Smith (1815–1877), American theologian |
| Sir Henry George Wakelyn Smith (1788–1860), British general |
| Henry John Stephen Smith (1826–1883), English mathematician |
| Henry Preserved Smith (1847–1927), American biblical scholar |
| James Smith (1719–1806), signer of the Declaration of Independence |
| James (1775–1839) and Horace (1779–1849) Smith, authors of the Rejected Addresses |
| Captain John Smith (1580–1631), sometime President of the English colony in Virginia |
| John Raphael Smith (1752–1812), English painter and mezzotint engraver |
| Joseph Smith (1805–1844), Founder of the Church of Jesus Christ of Latter-Day Saints |
| Morgan Lewis Smith (1822–1874), American general |
| Richard Baird Smith (1818–1861), British engineer officer |
| Robert Smith (1689–1768), English mathematician |
| Roswell Smith (1829–1892), American publisher |
| Samuel Francis Smith (1808–1895), American clergyman and hymn-writer |
| Southwood Smith (1788–1861), English physician and sanitary reformer |
| Sydney Smith (1771–1845), English writer and divine |
| Sir Thomas Smith (1513–1577), English scholar and diplomatist |
| William Smith (fl. 1596), English sonneteer |
| William Smith (c. 1730–1819), English actor |
| William Smith (1769–1839), English geologist |
| Sir William Smith (1813–1893), English lexicographer |
| William Farrar Smith (1824–1903), American general |
| William Henry Smith (1808–1872), English author |
| William Henry Smith (1825–1891), English man of business and statesman |
| William Henry Smith (1833–1896), American newspaper man |
| William Robertson Smith (1846–1894), Scottish philologist, physicist, archæologist, biblical critic, and editor of the Encyclopædia Britannica |
| Sir William Sidney Smith (1764–1840), English admiral |
| James Smithson (1765–1829), British chemist and mineralogist and founder of the Smithsonian Institution |
| Perez Smolenskin (1842–1885), Russian Jewish novelist |
| Tobias George Smollett (1721–1771), British novelist |
| Reed Smoot (1862–1941), American politician |
| Jan Christiaan Smuts (1870–1950), South African statesman |
| Charles Piazzi Smyth (1819–1900), British astronomer |
| Ethel Smyth (1858–1944), English musical composer |
| Herbert Weir Smyth (1857–1937), American classical scholar |
| John Smyth (c. 1570–1612), English nonconformist divine |
| Warington Wilkinson Smyth (1817–1890), British geologist |
| William Smyth (c. 1460–1514), Bishop of Lincoln |
| Hannah Snell (1723–1792), the “female soldier” |
| John Snell (1629–1679), founder of the Snell exhibitions at Oxford |
| Snellius (1580–1626), Dutch astronomer and mathematician |
| Carl Snoilsky (1841–1903), Swedish poet |
| Snorri Sturluson (1179?–1241), celebrated Icelandic historian |
| Phillip, Viscount Snowden (1864–1937), British Labour politician |
| Frans Snyders (1579–1657), Flemish painter of animals and still life |
| Sir John Soane (1753–1837), English architect and art collector |
| Socinus, name born by two Italian theologians |
| Socrates (469–399 B.C.), renowned Athenian philosopher |
| Socrates (c. 379–c. 440 A.D.), famous church historian |
| Hermann, Freiherr von Soden (1852–1914), German biblical scholar |
| Piero Soderini (1452–1522), Florentine statesman |
| Il Sodoma (1477?–1549), Italian painter |
| Sofia Alekseevna (1657–1704), Tsarevna and Regent of Russia |
| Antonio Solario (c. 1382–1455), Italian painter of the Neapolitan school |
| Clemente Solaro della Margarita (1792–1869), Piedmontese statesman |
| Emily Soldene (1838?–1912), English singer and actress |
| James Russell Soley (1850–1911), American educator and author |
| Wilhelm Heinrich Solf (1862–1936), German colonial politician |
| Gaius Julius Solinus (fl. Third Century?), Latin grammarian and compiler |
| Antonio de Solís (1610–1686), Spanish dramatist and historian |
| Solomon (Tenth Century B.C.), King of Israel |
| Solomon ibn Gabirol (Avicebron) (1021?–1058), Jewish poet and philosopher |
| Solon (c. 630–560 B.C.), Athenian statesman |
| John, Lord Somers (1651–1716), English Lord Chancellor |
| Earls and Dukes of Somerset |
| Edmund Beaufort, Duke of Somerset (c. 1404–1455), English noble |
| Edward Seymour, Duke of Somerset (c. 1506–1552), Protector of England |
| Isabella Caroline Somerset (1851–1921), English philanthropist |
| Robert Carr, Earl of Somerset (c. 1590–1645), Scottish politician |
| Lord Robert Edward Henry Somerset (1776–1842), British soldier |
| Mary Somerville (1780–1872), British scientific writer |
| William Somerville (1675–1742), English poet |
| William Sommers (d. 1560), court fool of Henry VIII. |
| Adolf von Sonnenthal (1834–1909), Austrian actor |
| Sidney Sonnino (1847–1922), Italian statesman and financier |
| Sophia (1630–1714), Electress of Hanover |
| Sophia Dorothea (1666–1726), wife of George I. of England |
| Sophocles (c. 496–406 B.C.), Greek tragic poet |
| Sophron (c. 470–400 B.C.), writer of mimes |
| Saint Sophronius (c. 560–c. 638), Greek “sophist” and theological writer |
| Soranus (fl. Second Century), Greek physician |
| Barea Soranus (First Century A.D.), Roman senator |
| Henry Clifton Sorby (1826–1908), English microscopist and geologist |
| Sordello (Thirteenth Century), Italian troubadour |
| Agnès Sorel (c. 1422–1450), mistress of King Charles VII. of France |
| Albert Sorel (1842–1906), French historian |
| Charles Sorel (1597?–1674), French novelist and miscellaneous writer |
| Joaquín Sorolla y Bastida (1863–1923), Spanish painter |
| Sosigenes (First Century B.C.), Greek astronomer and mathematician |
| Sositheus (c. 280 B.C.), Greek tragic poet |
| Sotades (Third Century B.C.), Greek satirist |
| Soter (d. 174), Pope |
| William Sotheby (1757–1833), English author |
| Edward Askew Sothern (1826–1881), English actor |
| Hernando de Soto (1500–1542), Spanish captain and explorer |
| Benjamin de Rohan, Seigneur de Soubise (1583–1642), Huguenot leader |
| Joseph Souham (1760–1837), French soldier |
| Joséphin Soulary (1815–1891), French poet |
| Pierre Soulé (1801–1870), American statesman and soldier |
| Nicolas-Jean de Dieu Soult (1769–1851), Marshal of France |
| Alexandre Soumet (1788–1845), French poet |
| Luís de Sousa (1555?–1632), Portuguese monk and prose-writer |
| John Philip Sousa (1854–1932), American orchestra and band leader and composer |
| Robert South (1634–1716), English divine |
| Earl of Southampton |
| Henry Wriothesley, Earl of Southampton (1573–1624), one of Shakespeare’s patrons |
| Joanna Southcott (1750–1814), English religious fanatic |
| Thomas Southerne (1660–1746), English dramatist |
| Caroline Bowles Southey (1786–1854), English poet |
| Robert Southey (1774–1843), English poet and man of letters |
| Robert Southwell (c. 1561–1595), English Jesuit and poet |
| Constant Southworth (1614–1679), New England colonist |
| Emma Dorothy Eliza Nevitte Southworth (1819–1899), American novelist |
| Émile Souvestre (1806–1854), French novelist |
| Gilles de Souvré, Marquis de Courtanvaux, Baron de Lezines (c. 1540–1626), Marshal of France |
| Adélaïde Filleul, Marquise de Souza-Botelho (1761–1836), French writer |
| James Sowerby (1757–1822), English natural-history artist |
| Alexis Soyer (1809–1858), French culinary artist |
| Sozomen (c. 400–450), famous church historian |
| Lo Spagna (c. 1450–1528), Italian painter |
| William Spalding (1809–1859), British author |
| Lazaro Spallanzani (1729–1799), Italian man of science |
| August Gottlieb Spangenberg (1704–1792), Bishop of the Moravian Brethren |
| Jared Sparks (1789–1866), American historian and educationalist |
| Spartacus (d. 71 B.C.), leader in the Slave or Gladiatorial War against Rome |
| James Spedding (1808–1881), English author, editor of the works of Bacon |
| Maximilian von Spee (1861–1914), German admiral |
| John Speed (1552?–1629), English historian and cartographer |
| Hugh Speke (1656–c. 1724), English writer and agitator |
| John Hanning Speke (1827–1864), English explorer, discoverer of the source of the Nile |
| Sir Henry Spelman (c. 1564–1641), English antiquary |
| Joseph Spence (1699–1768), amiable English writer |
| Thomas Spence (1750–1814), inventor of a system of land nationalization |
| Herbert Spencer (1820–1903), English philosopher |
| John Charles, Earl Spencer (1782–1845), English statesman |
| John Poyntz, Earl Spencer (1835–1910), English statesman |
| Sara Jane Andrews Spencer (1837–1909), American reform advocate |
| William Robert Spencer (1770–1834), English poet and wit |
| Philipp Jakob Spener (1635–1705), German theologian |
| Thomas de Spens (c. 1415–1480), Scottish statesman and prelate |
| Edmund Spenser (1552?–1599), English poet |
| John Spenser (1559–1614), President of Corpus Christi College, Oxford |
| Mikhail Mikhailovich Speranski (1772–1839), Russian statesman |
| Speusippus (Fourth Century B.C.), Greek philosopher |
| Friedrich Spielhagen (1829–1911), German novelist |
| Richard Phené Spiers (1838–1916), English architect and author |
| Christian Heinrich Spiess (1755–1799), German writer of romances |
| Spinello Aretino (c. 1350–1410), Italian painter |
| Ambrogio Spinola (1569–1630), Spanish general
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