A period of sickness or trouble.

1

1862.  We had a siege of it.—Atlantic Monthly, ix. 558/2 (May).

2

1902.  For a while they have a siege of discontent, wondering where it’s all gone.—W. N. Harben, ‘Abner Daniel,’ pp. 57–8.

3

1908.  She was as pale and peaked as if she had been through a siege of typhoid.—Eliza C. Hall, ‘Aunt Jane of Kentucky,’ p. 9.

4