A period of sickness or trouble.
1862. We had a siege of it.Atlantic Monthly, ix. 558/2 (May).
1902. For a while they have a siege of discontent, wondering where its all gone.W. N. Harben, Abner Daniel, pp. 578.
1908. She was as pale and peaked as if she had been through a siege of typhoid.Eliza C. Hall, Aunt Jane of Kentucky, p. 9.