Comprehensively.
1833. The air of a man who has heard of the biter bit, and feels rather perplexed on the whole, take it by-and-large.John Neal, The Down-Easters, i. 23.
1845. He had been speaking for four hours, ostensibly on the Panama mission, but actually travelled over everything by and large.Cornelius Mathews, Writings, ii. 159.
1857. I know what women be. Ive wintered and summered with em, and take em by and large, theyre bettern men.J. G. Holland, The Bay-Path, p. 172.
1869. Taking it by and large, as the sailors say, we had a pleasant ten days run from New York to the Azores islands.Mark Twain, The Innocents Abroad, chap. v.
1875. Taking you by-and-large, you do seem to be more different kinds of an ass than any creature I ever saw before.Mark Twain, Old Times on the Mississippi, Atlantic Monthly, xxxv. p. 285/1 (March).
1906. Considered by and large, the canals seem to be equally distributed rount the compass points; and this at all longitudes and nearly all latitudes.Percival Lowell, Mars and its Canals, p. 188.