Physiol. Chem. [app. for *tripsin, f. Gr. τρῖψις rubbing (because first obtained by rubbing down the pancreas with glycerin) + -IN1.] The chief digestive ferment of the pancreatic juice, which converts proteins into peptones. Hence Trypsinogen [-GEN 1], a granular substance occurring in the pancreas, from which trypsin is formed; Trypsogen [abbrev. of prec.]. (a) = trypsinogen; (b) a drug prepared from trypsin and other ferments with gold and arsenic bromides, used in diabetes, etc. (Dorland).
1876. Foster, Phys., II. i. (1879), 233. The digestive powers of the [pancreatic] juice … depend … on the presence of a ferment, to which the name *trypsin has been given.
1907. Westm. Gaz., 12 Dec., 12/2. The new treatment of cancer by the pancreatic ferments, trypsin and amylopsin … suggested by Dr. Beard.
1890. Billings, Med. Dict., *Trypsinogen.
1900. Lancet, 27 Oct., 1187/1. The fact observed by Heidenhain of the continuous formation and storing up trypsinogen in the pancreas, and its subsequent transformation into trypsin during the culmen of gastric digestion, proved that the former substance … enjoyed an origin quite independent of all influence outside the pancreas.
1907. H. W. Bettmann, in Med. Record, 3 Aug., 171. The intestinal juice contains two other ferments…, enterokinase, and erepsin. The former activates the pancreatic juice by transforming trypsinogen into trypsin.
1883. Science, I. 372/1. The absence of oxygen from the blood has led to a reconversion of trypsin into *trypsogen.
