[f. TREPAN v.1 + -ATION; cf. F. trépanation (14th c. in tr. of Lanfranc).] The operation of trepanning; perforation of a bone, esp. of the skull, by a trepan.
c. 1400. Lanfranc’s Cirurg., 126. & þese, in as myche as touchinge trepanacioun, worchiþ best.
1597. A. M., trans. Guillemeau’s Fr. Chirurg., 56 b/2. Opinione of Avicenna touchinge trepanatione.
1882. Athenæum, 16 Dec., 817/2. Numerous cases of surgical and posthumous trepanation.
