ppl. a. U.S. [f. LOCO1 + -ED.] Affected with or poisoned with loco; also transf. of a person (see quot. 1892).

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1886.  Cornh. Mag., Sept., 298. About two hundred and fifty ‘locoed’ horses, which had been driven in the fall from the region where ‘loco’ flourished…. In addition to being badly locoed and half-starved, the majority suffered from Spanish itch.

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1892.  Chamb. Jrnl., 17 Dec., 816/2. In localities where loco is found,… if people are deficient in intellect, or odd and eccentric, they are designated ‘locoed!’

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